Artemis August 2017 — Johns Hopkins Breast Cancer Center

Genetic Predisposition to Breast Cancer Due to Non-BRCA Mutations in Ashkenazi Jewish Women

Johns Hopkins BRCA Cancer Study

Genetic mutations in BRCA1 and BRCA2 increase the risk of breast and ovarian cancer in Ashkenazi Jewish women. A new article published in the journal JAMA Oncology examines the likelihood of carrying another cancer-predisposing mutation in BRCA1, BRCA2 or another breast cancer gene among women of Ashkenazi Jewish ancestry with breast cancer who do not carry one of the founder mutations.

Mary-Claire King, Ph.D., of the University of Washington, Seattle, and coauthors sequenced genomic DNA of 1,007 women of Ashkenazi Jewish ancestry with breast cancer for known and candidate breast cancer genes.

Of the 1,007 patients in the study, 903 had none of the three founder mutations in BRCA1 or BRCA2. Of those 903 patients, seven (0.8 percent) carried a different mutation in BRCA1 or BRCA2 and 31 (3.4 percent) carried a damaging mutation in another breast cancer gene, according to the results.

The study notes two limitations, including that only genes known or suspected to harbor mutations increasing the risk of breast cancer were sequenced.

“Ashkenazi Jewish patients with breast cancer can benefit from genetic testing for all breast cancer genes,” the article concludes.

SOURCE:JAMA Oncology, July 20, 2017

Ilene

Female. East coast transplant living in the Bay Area of California. Living with Stage IV breast cancer. Married to the coolest guy in the universe who occasionally suffers from serious depression. Love my stepsons, although I never thought I'd have that thankless job - ever! And my best friend Simon is also my cat. How I have survived with stage IV: treatments including chemo and surgery; palliative oncology; tenacity; a dark sense of humor; support groups; and my newly reinvented career as a vintage and antiques maven. Some days I miss the old me who led a well respected and well paid life as a business strategist in high tech. So much for that. I blog to simply share my experiences and my poetic approach with others who have cancer of any kind or with their care givers and those who love them. If one person at the very least finds a little commonality or a friend out in the ether tor a smile, a common nod about this experience, or even a link to assistance, then I have accomplished a small but extraordinarily meaningful goal. Go team.

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